Cosmetic ingredient

MADECASSOSIDE

MADECASSOSIDE is a triterpene saponin found in Centella asiatica, a plant also known as gotu kola. It is not the plant’s whole extract: it is one isolated constituent, described as a trisaccharide derivative of madecassic acid.

Molecular structure of MADECASSOSIDE
2D molecular structure
CAS number
34540-22-2
EC number
252-076-1
Molecular formula
C48H78O20
Molecular weight
975.1
Chemical name
O-6-Deoxy-α-L-mannopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl (2α,3β,4α,6β)-2,3,6,23-tetrahydroxyurs-12-en-28-oate
InChIKey
BNMGUJRJUUDLHW-HCZMHFOYSA-N

MADECASSOSIDE: what it is

MADECASSOSIDE is a triterpene saponin found in Centella asiatica, a plant also known as gotu kola. It is not the plant’s whole extract: it is one isolated constituent, described as a trisaccharide derivative of madecassic acid.

That distinction matters when comparing labels. A Centella asiatica extract can contain many plant constituents, whereas MADECASSOSIDE identifies this particular molecule. Its botanical origin explains why the names are connected, but an ingredient list alone cannot show how the raw material was obtained or how much was used in the formula.

MADECASSOSIDE: what it does in cosmetics

In cosmetics, MADECASSOSIDE is listed as an antioxidant and skin-conditioning ingredient. As an antioxidant, it can help limit oxidation processes within the formula; as a skin-conditioning ingredient, it is used to support a softer, more comfortable skin feel, depending on the finished product.

Laboratory research has examined isolated madecassoside in skin cells, but that setting does not reproduce everyday cosmetic use in people. One six-month trial in 20 women tested a topical preparation containing 5% vitamin C and 0.1% madecassoside; because both actives were used together, the findings cannot assign changes in appearance or hydration to madecassoside alone.

Catalogue presence

Products containing this ingredient

See which products include it and the name used in each composition.