Cosmetic ingredient

CHLORHEXIDINE DIHYDROCHLORIDE

CHLORHEXIDINE DIHYDROCHLORIDE is the hydrochloride salt of chlorhexidine. Chlorhexidine belongs to the guanidine group, and the chlorhexidine portion is associated with the antimicrobial activity seen in laboratory testing.

Molecular structure of CHLORHEXIDINE DIHYDROCHLORIDE
2D molecular structure
CAS number
3697-42-5
EC number
223-026-6
Molecular formula
C22H32Cl4N10
Molecular weight
578.4
Chemical name
N,N'-bis(4-Chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine dihydrochloride
InChIKey
WJLVQTJZDCGNJN-UHFFFAOYSA-N

CHLORHEXIDINE DIHYDROCHLORIDE: what it is

CHLORHEXIDINE DIHYDROCHLORIDE is the hydrochloride salt of chlorhexidine. Chlorhexidine belongs to the guanidine group, and the chlorhexidine portion is associated with the antimicrobial activity seen in laboratory testing.

The word “dihydrochloride” identifies this particular salt form; it is not interchangeable with chlorhexidine digluconate or chlorhexidine diacetate. Those materials share the same underlying chlorhexidine component, but their salt forms differ, so a label or concentration for one should not be assumed to describe another.

CHLORHEXIDINE DIHYDROCHLORIDE: what it does in cosmetics

In cosmetics, chlorhexidine dihydrochloride can be used as a preservative. In practical terms, it helps limit the growth of microorganisms that could spoil a product while it is being used. Its oral-care role relates to products intended for the mouth and to hygiene routines.

Laboratory research has tested chlorhexidine dihydrochloride against bacteria, including in systems designed to measure the susceptibility of clinical isolates. That evidence gives context for its antimicrobial role, but it does not show that a particular cosmetic treats infections, gum disease, acne, or any other health condition.

CHLORHEXIDINE DIHYDROCHLORIDE: conditions and care

Chlorhexidine dihydrochloride is subject to a use restriction. A cosmetic safety assessment examined this salt form at concentrations up to 0.16%; the concentration and manner of use of a product must comply with the applicable rules.

Use limits

Restrictions and conditions of use

Cosmetic restriction
V/42
Catalogue presence

Products containing this ingredient

See which products include it and the name used in each composition.